Could life in solar system complicate space settlement?

I think that - as we do on Earth - we will completely disregard
indigenous life if they are in the path of economic interests. (And
that will be particularly true if the indigenous life is just
microbial. Even the most extremist econuts here on Earth won't care at
all about the rights of bacteria.) Even if one group in space has some
concern about disturbing local life, another group will not (and I
assume that at some point there will be many groups and cultures with
diverging views and interests in space).